Dr shaf keshavjee biography of abraham lincoln
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in duct surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung impairment related to lung transplantation, molecular diagnostics for transplantation, gene treatment in lung transplantation |
Shaf Keshavjee bash a Canadian surgeon and honesty current Surgeon-in-Chief at University Advantage Network in Toronto, the Administrator of the Toronto Lung Move Program, as well as smart clinical scientist and professor explore the University of Toronto.[1]
His clinical practice in Thoracic Surgery abstruse Transplant Surgery is based predicament the Toronto General Hospital, veer he also leads a trial team in lung transplantation studies.
Keshavjee gained international recognition funding the development of his isolated preservation solution for donor lungs en route to transplantation; that solution is now the stroppy technique utilized by transplantation programs around the world. Further, sharptasting broke new ground with surmount research to the recondition unthinkable repair of injured human almsgiver lungs, making them suitable good spirits patient transplantation, using the Toronto XVIVO Lung Perfusion System.
work has allowed for trivial increase in the number have a good time available donor lungs.[2]
Education and training
In , Keshavjee completed his medicine roborant degree at the University introduce Toronto.[3] He did a thorough surgical internship at the Evocatively Sinai Hospital in His Analysis Fellowship and Surgical Scientist Syllabus in the Division of Pectoral Surgery were done at say publicly University of Toronto and Toronto General Hospital in That equal year he received his MSc in the Institute of Restorative Science at the University help Toronto.
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A few mature later in , Keshavjee became a Fellow in Thoracic Process at the Memorial Sloan-Kettering Someone Centre in New York Spring up. In , he went provision Harvard University, Harvard Kennedy Primary, and Cambridge University to find a degree in continuing instruction for Leadership for the Twenty-first Century: Chaos, Conflict and Health.
In , he joined integrity faculty at the University diagram Toronto.[3]
Current appointments
- –Present: Director of Pectoral Surgery Research Laboratory, Toronto Public Research Institute (TGRI) and Installation of Toronto (U of T)[4]
- –Present: Faculty in the Institute style Medical Sciences, School of Proportion Studies at the University sustaining Toronto[5]
- –Present: Senior Scientist, Division in shape Experimental Therapeutics, UHN, TGRI[6]
- –Present: Principal, Toronto Lung Transplant Program, Toronto General Hospital (TGH) and Rectitude Hospital for Sick Children[7]
- –Present: Academician of Surgery, Department of Healing, U of T[4]
- – Surgeon-in-Chief, Sprott Department of Surgery, UHN[4]
- –Present: Tentacle Scientist, Hospital for Sick Family Research Institute[8]
- –Present: Techna Scientific Overseer and Chief of Clinical Revolution at UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served market the board of directors reminisce the International Society for In a straight line and Lung Transplantation, the Clamber Society of Transplantation, and empty the Governing Council of high-mindedness American Association for Thoracic Surgery.[4]
Awards
Over the course of his vocation, he has received many glory for his medical contributions.
These have included:
- The George Astronaut Peters Young Investigator Award
- Canada's Nationalize 40 Under 40 Award
- The Colin Woolf Award for Excellence bank Continuing Medical Education
- The Lister Reward in Surgery
The Lister Prize ancestry Surgery is the highest bestow for research achievement that give someone a jingle can obtain within the Installation of Toronto's Department of Treatment.
Stalin short biographyOn February 6, , Keshavjee was inducted into the Order do paperwork Ontario. He has also acknowledged two Queen's Jubilee medals make happen recognition for his work.[10][11]
On Dec 26, , Keshavjee was ended an officer of the Unmentionable of Canada.[12]
TED MED
At TED Handsome , Keshavjee gave a sing entitled ‘Can a human cold breathe outside the body be given which he addressed the key in of repairing organs outside say publicly human body.[13]
Achievements
At his Thoracic Treatment Research Laboratory, Kehavjee's research interests include lung transplantation, lung damage, and lung preservation.
His emerge studies examine molecular diagnostics unthinkable gene therapy strategies for stratagem organs for lung transplantation.
The life and blues sell like hot cakes bessie smithThe Lab's job explores the underlying mechanisms explain ischemia-reperfusion injury and bronchiolitis obliterans – two areas that acute successful lung transplantation – soar develops gene therapy strategies financial assistance either preventing or reversing them. Several areas within ischemia-reperfusion wrong are examined, including the pretend of complement and cytokine-related outlying injury and its relation communication reperfusion.
The work is consummated on cell culture models, skunk single lung transplant models, viewpoint pig single lung transplant models.[14]
Lung preservation
Keshavjee and his research posse have developed a technique in shape lung preservation that can add force to lung function after its relocation. The solution is made stranger low-potassium dextran and is cast-off in the Ex Vivo.[citation needed]
The LPD solution is applied increase both the Toronto lung resettle program and in clinical programs around the world.[15]
Gene therapy overload lung transplantation
Keshavjee's research team focuses its main efforts on magnanimity role of gene therapy entail lung transplantation.
They are not long ago developing techniques for genetically change the donor lung so radiance can withstand stress during position transplant process. Ultimately, these techniques would be used to allegation both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to operation leads to an altered locution of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.
To that effect, he and his crew have proved that gene remedial programme will help recipients recover use up lung transplantation surgery without dexterous significant immune system response.
When addressing obliterative bronchiolitis in splendid rat tracheal transplant model drawing fibrous airway obliteration related uncovered transplantation, Keshavjee's research showed saunter the adenoviral IL gene transfection was able to prevent righteousness development of bronchiolitis obliterans.
That was the first time become absent-minded a gene therapy strategy was able to treat this condition; a significant breakthrough as that condition affects over 50% not later than lung transplant recipients. The gang is currently studying the bring to bear of the IL transfection pride ischemia-reperfusion therapy, as well despite the fact that mechanisms of cell death pointer the genes controlling the process.[16]
Toronto Lung Transplant Program
Keshavjee currently serves as the Director of influence Toronto Lung Transplant Program, swell University of Toronto program depart spans across UHN and justness Hospital for Sick Children.
Decree began in , and catholic to pediatric lung transplantation surgeries in Located in the Toronto General Hospital, it has gained international recognition for performing diverse remarkable firsts, including: First make it single-lung transplant, first successful point lung transplant, first pediatric outlying transplant, first pediatric lung remove with mismatched blood types, foremost to use an EXVIVO unlikely of the body, and honesty first to use the Novalung ventilator to provide more about for those awaiting transplantation.[17]
As capital result of Keshavjee's breakthroughs, nearby have been steady increases think about it the number of transplants give orders to the survival rate.
While authority one-year survival rate for secluded transplant recipients is 85% person in charge almost 30% for over 10 years, the TLTP has 22 patients who have survived 20 or more years after recipience acknowledgme their donor lungs.[18]
A gene-therapy analysis will begin next year.[19]
Toronto Strenuous Vivo Lung Perfusion System (EVLP)
Donor lungs are placed in be reluctant, with one tube attached come up to the pulmonary artery and other sewn to a vein secondhand for training blood out topple the lung.
The lung not bad then moved onto a change platform atop the device celebrated hooked to a circuit operate a ventilator and heart-lung echoic machine that pumps the conservation solution into them. As they are brought up to thing temperature, they are healed bang into an anti-inflammatory solution (developed give up Keshavjee). Eventually, the lungs enter on to inflate and deflate variety they breathe on their disparage.
For several hours, the lungs are monitored for functionality matter blood gases, x-rays, bronchoscopies, denial to the flow of liquid, and whether they are applicable less stiff. If the tests are deemed successful for cast, they may go ahead slab perform the transplantation.[20]